10-4937
MS102
Size
£168.00
- SKU:
- 10-4937
- Physical State:
- Solid
- Molecular Weight:
- 596.44
- Purity:
- >98%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- Immunogen:
- DUB (Deubiquitinating enzyme)
- Extra Details:
- MS102 is an orally bioavailable derivative (IC50 = 5.46 uM) of the USP2 inhibitor ML364.1 It displayed improved USP2 inhibition efficacy and improved antiviral activity (SARS-CoV-2 HepG2 and Calu-3 cells) compared to ML364. Antiviral activity of MS102 is via inhibition of the deubquitinase activity of USP2 on ACE2 resulting in reduction of ACE2 levels. MS102 significantly reduces V-domain Ig suppressor of T cell activation (VISTA) protein abundance in syngeneic mouse tumor models to enhance T cell response and synergizes with anti-PD-1 immunotherapy.2
- Shipping Conditions:
- Ambient