Chroman 1

Size

£144.00

SKU:: 10-4912
Physical State:: Solid
Molecular Weight:: 436.51
Purity:: 99%
Purification:: HPLC Purified
Storage Conditions:: -20[o]C
Supplier:: Focus Biomolecules
CAS Number:: 1273579-40-0
Immunogen:: Kinase
Extra Details:: Extremely potent inhibitor of Rho kinase II (ROCK-II)1,2 - it displayed greater selectivity and potency compared to Y-27632 (IC50's: ROCK I = 52 pM/ROCK II = 1 pM; Y-27632 IC50's: ROCK I = 71 nM/ROCK II = 46 nM)3. Chroman 1, used in conjunction with trans-ISRIB (Cat# 10-1539), Emricasan (Cat# 10-4280), and polyamines (CEPT cocktail), promotes cytoprotective cell survival in human pluripotent stem cells (hPSCs) and was found to superior to Y-27632.3 Chroman 1 is an important new tool in the generation and maintenance of stem cells.