10-4908
I2
Size
£173.00
- SKU:
- 10-4908
- Physical State:
- Orange/red solid
- Molecular Weight:
- 451.23
- Purity:
- 98%
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- Unknown
- ABP:
- No Import Docs
- Immunogen:
- UPR (Unfolded protein response)
- Extra Details:
- I2 is an inhibitor of the oxidoreductase ERO1A (IC50 = 8.1 uM), a mediator of the unfolded protein response (UPR).1 Under cancer-related hypoxia conditions, ERO1A favors the folding of the angiogenic protein VEGFA leading to cancer cell growth and spread. I2 inhibited the metabolic activity of DMA-MB-231 triple negative breast cancer cells and impaired migration and VEGF secretion. Tumors in C57/BL6Jmice showed decreased levels of VEGF and PD-L1 when treated with I2.
- Shipping Conditions:
- Ambient