10-4897
Fexaramine
Size
£158.00
- SKU:
- 10-4897
- Physical State:
- Solid
- Molecular Weight:
- 496.65
- Purity:
- >98%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 574013-66-4
- Immunogen:
- Transcription factor
- Extra Details:
- Fexaramine is a potent (EC50 = 25 nM) and selective agonist of the nuclear bile acid receptor FXR.1 It significantly enhanced osteoblastic differentiation and suppressed osteoclast differentiation from bone marrow macrophages.2 Fexaramine induces enteric FGF15 and reduces diet-induced weight gain, body-wide inflammation, and hepatic glucose production while enhancing thermogenesis and browning of white adipose tissue.3 It protected mice from ethanol-induced liver injury4 and decreased lipid accumulation via hepatic fatty acid oxidation5.
- Shipping Conditions:
- Ambient