10-4881
Cucurbitacin B
Size
£177.00
- SKU:
- 10-4881
- Additional Names:
- SDZ HTF 919
- Physical State:
- Solid
- Molecular Weight:
- 558.71
- Purity:
- >98%
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 6199-67-3
- Immunogen:
- RNA
- Extra Details:
- Cucurbitacin B is a natural product isolated from the Cucurbitaceae family.1 It displays a broad range of pharmacological activities including anti-inflammatory, antioxidant, antiviral, hypoglycemic, hepato-and neuroprotection, and anti-cancer.1,2 Cucurbitacin B's activities are the result of regulation of diverse signaling pathways including JAK/STAT3, Nrf2/ARE, NFkB, AMPK, MAPK, and others. It has recently been shown to block the m6A RNA reader protein IGF2BP1 (IC50 = 4.1 uM and 1.0 uM @ 24 and 72 hr respectively).3 IGF2BP1 blockade in hepatocellular carcinoma cells leads to apoptosis and subsequent recruitment of immune cells to the tumor microenvironment and PD-L1 blockade.
- Shipping Conditions:
- Ambient