10-4872
LD2
Size
£158.00
- SKU:
- 10-4872
- Physical State:
- Solid
- Molecular Weight:
- 247.68
- Purity:
- >98%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 1134334-55-6
- Immunogen:
- Protein methyltransferase
- Extra Details:
- LD2 is a protein arginine N-methyltransferase 9 (PRMT9) inhibitor. It inhibited the viability of leukemia cells (IC50 = 2-7 uM in various cell lines). LD2 promoted DNA damage leading to cyclic GMP-AMP synthase (cGAS) activation and a type I IFN response. LD2 acted synergistically with anti-PD-1 mAb in an A20 lymphoma syngeneic model, an MA9 AML transplant model as well as a humanized AML mouse model. LD2 treatment led to leukemia stem cell ablation as well as an anticancer immune response.
- Shipping Conditions:
- Ambient