10-4866
NR2E3 agonist 11a
Size
£197.00
- SKU:
- 10-4866
- Physical State:
- Solid
- Molecular Weight:
- 430.89
- Purity:
- >98%
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 911211-69-3
- Immunogen:
- Transcription factor
- Extra Details:
- 11a is an agonist of the photoreceptor-specific nuclear receptor (NR2E3; PNR; RNR), found in rod photoreceptor cells (EC50 = 141 nM B Beta-lactamase assay; 35 nM NCOR assay).1 An interesting tool for targeting age-related macular degeneration. 11a was able to increase p53 activation in uterine cancer tumors suggesting NR2E3 agonism as a new anti-cancer strategy.2 A previous study found that cytotoxicity of 11a was due to G1/S phase cell cycle arrest rather than NR2E3 agonism.3
- Shipping Conditions:
- Ambient