10-4862
UH15-38 2HCl
Size
£177.00
- SKU:
- 10-4862
- Physical State:
- Solid
- Molecular Weight:
- 514.45
- Purity:
- >98%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 2540881-21-6
- Immunogen:
- Kinase
- Extra Details:
- UH15-38 is a potent (IC50 = 20 nM) inhibitor of RIPK3 with excellent cellular activity. It blocked TNF-induced necroptosis in primary mouse embryonic fibroblasts (IC50 = 98 nM). UH15-38 selectively blocked influenza A-induced necroptosis over apoptosis in mouse alveolar epithelial cells, mouse embryonic fibroblasts, and human M29 cells at nanomolar levels. It attenuated influenza A-induced lung injury and lethality in vivo.
- Shipping Conditions:
- Ambient