10-4858
NVP-2
Size
£182.00
- SKU:
- 10-4858
- Physical State:
- Solid
- Molecular Weight:
- 513.08
- Purity:
- >98%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 1263373-43-8
- Immunogen:
- Kinase
- Extra Details:
- NVP-2 is a highly selective and potent (IC50 = 0.514 nM) inhibitor of cyclin dependent kinase 9 (CDK9).1 It inhibited proliferation of MOLT4 cells (IC50 = 9 nM). Treatment of cells with NVP-2 resulted in profound downregulation of core regulatory circuitry genes. It has also been shown to be a potent inhibitor of CDK10 (IC50 = 29 nM; this study gives an IC50 of 6 nM for CDK9).2 NVP-2 acted synergistically with orlistat to inhibit acute myeloid leukemia cells (IC50s: Kasumi-1 cells 7.58 nM; U937 cells 8.99 nM).3
- Shipping Conditions:
- Ambient