10-4857
UCB9608
Size
£192.00
- SKU:
- 10-4857
- Physical State:
- Solid
- Molecular Weight:
- 410.48
- Purity:
- >98%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 1616413-96-7
- Immunogen:
- Kinase
- Extra Details:
- UCB9608 is a potent (IC50 = 5 nM), highly selective, and orally bioavailable inhibitor of the phosphatidylinositol kinase PI4KIIIB Beta.1 It acts as a potent immunosuppressive agent (IC50 = 37 nM human mixed lymphocyte reaction (HuMLR) assay) and was able to significantly prolong heterotopic allograft retention in a mouse model of cardiac allograft rejection. UCB9608 preserved graft tolerance in mice carrying a heterotopic allogenic heart challenged with host-type melanoma and subsequently treated with antitumor immunotherapy.2 UCB9608 promoted a T cell regulatory phenotype over an effector phenotype.3
- Shipping Conditions:
- Ambient