10-4850
SR-717
Size
£177.00
- SKU:
- 10-4850
- Physical State:
- Solid
- Molecular Weight:
- 381.27
- Purity:
- >98%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 2375421-09-1
- ABP:
- No Import Docs
- Immunogen:
- STING
- Extra Details:
- Cell permeable and exceptionally selective STING agonist (IC50 = 7.8 uM). It displayed robust antitumor activity in B16.F10 melanoma and MC38 colorectal adenocarcinoma mouse models. SR-717 promoted the activation of CD8+ T, natural killer, and dendritic cells as well as promoting antigen cross-priming. It was able to induce PD-L1 expression in THP1 cells and in primary human PBMC's.
- Shipping Conditions:
- Ambient