10-4842
JTE-607
Size
£158.00
- SKU:
- 10-4842
- Physical State:
- Solid
- Molecular Weight:
- 597.36
- Purity:
- 98%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 188791-09-5
- Immunogen:
- RNA
- Extra Details:
- JTE-607 inhibits inflammatory cytokine production in human peripheral blood mononuclear cells (PBMC's) without causing immunosuppression: IC50's = 11 nM (TNF-), 5.9 nM (IL-1), 8.8 nM (IL-6), 7.3 nM (IL-8), and 9.1 nM (IL-10).1 It displayed efficacy in a mouse model of septic shock.2 JTE-607 also showed inhibitory activity against acute myelogenous leukemia cell lines.3,4 Recently, the mechanism of action of JTE-607 (a pro-drug, with the active species being the free acid) has been found to be inhibition of pre-messenger RNA endonuclease Cleavage and Polyadenylation Specificity Factor 3 (CPSF3).5,6 This prevents release of newly synthesized mRNA's resulting in read-through transcription and the formation of DNA-RNA hybrid R-loop structures. Transcripts down-regulated by JTE-607 were related to DNA damage-based phenotype
- Shipping Conditions:
- Ambient