10-4832
Larotrectinib
Size
£158.00
- SKU:
- 10-4832
- Additional Names:
- ARRY-470|LOXO-101
- Physical State:
- Solid
- Molecular Weight:
- 428.44
- Purity:
- 98%
- Purification:
- HPLC Purified
- Storage Conditions:
- RT
- Supplier:
- Focus Biomolecules
- CAS Number:
- 1223403-58-4
- Immunogen:
- Cytoskeleton|Kinase
- Extra Details:
- Larotrectinib is a potent (IC50's < 11 nM) inhibitor of tropomyosin receptor kinases A, B, and C (TrkA, B, and C).1 It is >100 fold selective against a panel of 229 kinases. Larotrectinib markedly attenuated bone cancer pain and significantly blocked the formation of neuroma-like structures and the sprouting of sensory nerve fibers. Larotrectinib caused substantial tumor regression in various cancers displaying TRK gene fusions.2-4 Larotrectinib is the first tissue agnostic drug approved by the FDA.
- Shipping Conditions:
- Ambient