WP1066

Size

£177.00

SKU:: 10-4831
Physical State:: Solid
Molecular Weight:: 356.22
Purity:: 98%
Purification:: HPLC Purified
Storage Conditions:: -20[o]C
Supplier:: Focus Biomolecules
CAS Number:: 857064-38-1
Immunogen:: Kinase|Transcription factor
Extra Details:: WP1066 (857064-38-1) is an inhibitor of the JAK2/STAT3 pathway as well as STAT5 and AKT.1,2,3 It downregulated Bcl-XL, Mcl-1, and c-myc while activating Bax and inducing apoptosis.1 Active against human malignant glioma U87-MG (IC50 = 5.6uM) and U373-MG (IC50 = 3.7uM) cells. Enhances T-cell cytotoxicity via inhibition of regulatory T-cells.4,5 WP1066 abrogated PD-L1 expression in lymphoma cell lines.6