10-4828
Defactinib
Size
£163.00
- SKU:
- 10-4828
- Additional Names:
- PF-04554878|VS-6063
- Physical State:
- Solid
- Molecular Weight:
- 510.50
- Purity:
- 98%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 1073154-85-4
- Immunogen:
- Kinase
- Extra Details:
- Defactinib (1073154-85-4) is a potent inhibitor of FAK (IC50 = 0.6nM) and Pyk2 (IC50 = 0.6nM).1 It is active in vivo (EC50 = 26nM). FAK inhibition prevents tumor invasion and dissemination rather than tumor size reduction. Defactinib has been shown to preferentially target cancer stem cells in a mouse xenograft model of triple negative breast cancer.2 It is in multiple clinical trials for various cancers3 and in shows synergistic activity when used in combination with checkpoint immunotherapy 4-6.
- Shipping Conditions:
- Ambient