10-4810
NU7441
Size
£139.00
- SKU:
- 10-4810
- Additional Names:
- Ku-57788
- Physical State:
- Solid
- Molecular Weight:
- 413.49
- Purity:
- 98%
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 503468-95-9
- Immunogen:
- Kinase
- Extra Details:
- NU7441 is a potent (IC50 = 13 nM) and selective ATP-competitive inhibitor of DNA-dependent protein kinase (DNA-PK).1,2 It increased the toxicity of ionizing radiation and etoposide on SW620 human colon cancer lines via impeding DNA double-strand break repair.3 NU7441 also increased the radio/chemosensitivity of various other cancer cell lines.3-6 Reduces the frequency of NHEJ repair while enhancing the rate of HDR repair following CRISPR/Cas9-mediated gene editing.7
- Shipping Conditions:
- Ambient