10-4809
Silmitasertib
Size
£163.00
- SKU:
- 10-4809
- Additional Names:
- CX-4945
- Physical State:
- Solid
- Molecular Weight:
- 349.77
- Purity:
- >98%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 1009820-21-6
- Immunogen:
- Kinase
- Extra Details:
- Silmitasertib is a potent and orally bioavailable inhibitor of casein kinase 2 (Ki=0.38 nM) acting at the ATP-binding site.1 It has been in preclinical and clinical development for a variety of cancers.2 It inhibits CK2-mediated phosphorylation of the SALL2 tumor suppressor preventing its proteasomal degradation and induces cell death in a variety of tumor cell lines.3 It inhibits fibroblast-like synoviocytes reducing rheumatoid arthritis disease severity in rodent models4 and inhibits collagen degradation5.
- Shipping Conditions:
- Ambient