10-4802
MTX-531
Size
£182.00
- SKU:
- 10-4802
- Physical State:
- Solid
- Molecular Weight:
- 453.95
- Purity:
- >98%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 2791417-66-6
- Immunogen:
- Kinase
- Extra Details:
- MTX-531 is a first-in-class dual EGFR/pan-PI3K inhibitor (IC50s: EGFR = 14.7 nM; PI3kA Alpha = 6.4 nM; PI3KB Beta = 233 nM; PI3KG Gamma = 8.3 nM; PI3KD Delta = 1.1 nM; mTOR = 105 nM; DNA-PK = 5.4 nM). MTX-531 displayed exquisite selectivity for EGFR and PI3K family members (against >400 protein/lipid kinases). It displayed efficacy in the treatment of head and neck squamous cell carcinomas and in combination with RAS inhibitors in BRAF-mutant and KRAS-mutant colorectal and pancreatic cancers. Additionally, it did not produce a hyperglycemic response that is typical for PI3K inhibitors. An interesting new chemical tool for cancer research that targets two key resistance drivers.
- Shipping Conditions:
- Ambient