10-4801
MK-2206
Size
£158.00
- SKU:
- 10-4801
- Physical State:
- Solid
- Molecular Weight:
- 480.39
- Purity:
- 98%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 1032350-13-2
- ABP:
- No Import Docs
- Immunogen:
- Kinase
- Extra Details:
- MK-2206 is a potent and selective allosteric inhibitor of Akt (IC50's: Akt1 = 5 nM, Akt2 = 12 nM, Akt3 = 65 nM) that enhances the in vitro and in vivo antitumor efficacy of several standard chemotherapeutic agents.1 It was able to decrease insulin-stimulated glucose uptake, glycogen synthesis and glycogen synthase activity in rat muscle.2 MK-2206 induced G1-phase cycle arrest and sensitized HepG2 hepatocellular carcinoma cells to TRAIL-induced apoptosis.3
- Shipping Conditions:
- Ambient