10-4796
SGC-GAK-1
Size
£153.00
- SKU:
- 10-4796
- Physical State:
- Solid
- Molecular Weight:
- 389.25
- Purity:
- 99%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 2226517-76-4
- Immunogen:
- Cytochrome/MDR|Kinase
- Extra Details:
- SGC-GAK-1 is a highly potent and selective inhibitor of cyclin G associated kinase (GAK), a member of the numb-associated kinase (NAK) family involved in membrane trafficking and sorting of proteins and is required for the maintenance of centrosome maturation and progression though mitosis. KD = 1.9 nM with >50-fold selectivity against a panel of 400 kinases. It also displayed affinity for RIPK2 (KD = 110 nM) and ADCK3 (KD = 190 nM). SGC-GAK-1 displayed potent cellular activity in HEK293T cells (IC50 = 120 nM) and showed strong growth inhibition in the prostate cancer cell lines LNCaP (IC50 = 0.65 uM) and 22Rv1 (IC50 = 0.17 uM).
- Shipping Conditions:
- Ambient