10-4793
Alectinib
Size
£158.00
- SKU:
- 10-4793
- Additional Names:
- CH5424802|RO5424802
- Physical State:
- Solid
- Molecular Weight:
- 482.62
- Purity:
- 99%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 1256580-46-7
- Immunogen:
- Kinase
- Extra Details:
- Alectinib is a potent (IC50 = 1.9 nM) and highly selective ALK inhibitor.1 It blocked phosphorylation of both native ALK and the L1196M, C1156Y, and F1174L mutants. Alectinib has also been shown to inhibit RET kinase (IC50 = 4.8 nM), the RET gatekeeper mutations V804L and V804M, and inhibited the growth of RET fusion positive cells.2 Alectinib is clinically useful in the treatment of ALK-positive Non-Small Cell Lung Cancer. It effectively suppressed cell proliferation and induced apoptosis in a mouse neuroblastoma xenograft.3
- Shipping Conditions:
- Ambient