10-4788
Duvelisib
Size
£163.00
- SKU:
- 10-4788
- Additional Names:
- IPI-145
- Physical State:
- Solid
- Molecular Weight:
- 416.87
- Purity:
- 98%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 1201438-56-3
- Immunogen:
- Kinase
- Extra Details:
- Duvelisib (1201438-56-3) is a potent and selective (IC50's: PI3KA Alpha = 1602nM, PI3KB Beta = 85nM, PI3KD Delta= 2.5nM, PI3KG Gamma = 27nM) dual PI3KD Delta/G Gamma inhibitor.1 It inhibits B and T cell proliferation, blocks neutrophil migration, and inhibits basophil activation. Duvelisib antagonizes B-cell receptor crosslinking activated pro-survival signals in primary chronic lymphocytic leukemia cells.2 Duvelisib also shows preclinical/clinical activity against other hematologic malignancies such as Non-Hodgkins lymphoma, T-cell lymphoma, ande others.3,4 Useful clinical agent for the treatment of various blood cancers. Low-dose treatment of T-cell-inflamed tumor models of head and neck cancers with Duvelisib enhanced responses to PD-L1 blockade via suppression of myeloid-derived suppressor cells.5 Higher doses reversed the effect due to suppression of tumor-infiltrating T lymphocytes
- Shipping Conditions:
- Ambient