10-4783
TGX-221
Size
£153.00
- SKU:
- 10-4783
- Additional Names:
- 7-Methyl-2-morpholino-9-(1-(phenylamino)ethyl)-4H-pyrido[1,2-a]pyrimidin-4-one
- Physical State:
- Solid
- Molecular Weight:
- 364.45
- Purity:
- 98%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 663619-89-4
- Immunogen:
- Kinase
- Extra Details:
- TGX-221 is a potent (IC50 = 5 nM) and selective (1000-fold over p110A Alpha and p110G Gamma) inhibitor of PI3-kinase isoform p110B Beta.1 Displays anti-thrombotic activity without affecting bleeding time.1,2 It significantly inhibited tumorigenesis in VHL, SETD2, PTEN, and CDKN2A mutated clear cell renal cell carcinoma.3 TGX-221 induced apoptosis in glioblastoma cells and inhibited cell migration and invasion.4
- Shipping Conditions:
- Ambient