10-4782
Crenolanib
Size
£158.00
- SKU:
- 10-4782
- Additional Names:
- CP-868,596
- Physical State:
- Solid
- Molecular Weight:
- 443.55
- Purity:
- 97%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 670220-88-9
- Immunogen:
- Kinase
- Extra Details:
- Crenolanib is a potent inhibitor of PDGFR (Kd for A Alpha = 2.1 nM; B Beta = 3.2 nM) and FLT3 (Kd = 0.74 nM).1 Crenolanib is a type I inhibitor binding only to the active kinase conformation. It showed potent activity against imatinib-resistant PDGFRA Alpha mutations D842I, D842V, D842Y, DI842-843M, and deletion I8432 as well as FLT3/ITD and FLT3/D835 mutants3. Crenolanib acted synergistically with FLT3-CAR T-cells in a FLT3-ITD+ AML murine xenograft model.4
- Shipping Conditions:
- Ambient