10-4781
AZD1208
Size
£153.00
- SKU:
- 10-4781
- Physical State:
- Solid
- Molecular Weight:
- 379.48
- Purity:
- 98%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 1204144-28-4
- Immunogen:
- Kinase
- Extra Details:
- AZD1208 is a highly selective and potent pan-PIM kinase inhibitor (IC50 = 3 nM PIM1; 150 nM PIM2; 9 nM PIM3).1 Displayed efficacy in models of acute myeloid leukemia2, prostate cancer3, and triple-negative breast cancer4. Combination treatment of AZD1208 and imatinib eliminated chronic myelogenous leukemia stem cells in cell culture and a patient-derived mouse xenograft model.5 It improved immunotherapeutic antitumor T-cell response6 and disrupted the myeloid cell-mediated immunosuppressive tumor microenvironment increasing T-cell-mediated antitumor immunity.
- Shipping Conditions:
- Ambient