10-4757
Ibrutinib
Size
£139.00
- SKU:
- 10-4757
- Additional Names:
- CRA-032765|PCI-32765
- Physical State:
- Solid
- Molecular Weight:
- 440.51
- Purity:
- 99%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 936563-96-1
- Immunogen:
- Kinase
- Extra Details:
- Ibrutinib (936563-96-1) is a very potent (IC50 = 0.5nM) irreversible inhibitor of Bruton tyrosine kinase (BTK) that blocks activation of the B-cell antigen receptor (BCR).1 Ibrutinib also potently inhibits several other kinases including BLK, BMS, FGR, EGFR, and ITK. It is a clinically useful drug to treat B cell cancers. It inhibits CLL cell migration and survival2,3 and downregulates expression of CD204. It enhanced antitumor immune responses in combination with anti PD-L1 blockade via its inhibition of ITK (IL2-inducible T-cell kinase).5
- Shipping Conditions:
- Ambient