10-4756
Deucravacitinib
Size
£197.00
- SKU:
- 10-4756
- Additional Names:
- BMS-986165
- Physical State:
- Solid
- Molecular Weight:
- 425.47
- Purity:
- 98%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 1609392-27-9
- Immunogen:
- Kinase
- Extra Details:
- Deucravacitinib is very potent and selective allosteric inhibitor of tyrosine kinase 2 (TYK2). It binds to and is selective for the TYK2 pseudokinase domain (JH2, IC50 = 0.2 nM), with no activity against canonical JH1 domain of TYK2, JAK1,2, or 3.1 It is 5-fold less active against the JAK1 JH2 domain (IC50 = 1 nM). Deucravacitinib blocked signaling and functional responses in human TH17, TH1, B cells, and myeloid cells and displayed robust efficacy in vitro and in vivo in autoimmune disease animal models.2
- Shipping Conditions:
- Ambient