10-4746
MU1700
Size
£192.00
- SKU:
- 10-4746
- Physical State:
- Solid
- Molecular Weight:
- 479.41
- Purity:
- >98%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 1360905-04-9
- Immunogen:
- Kinase
- Extra Details:
- MU1700 is a potent (IC50's = 13 nM ALK1; 6 nM ALK2) and highly selective (selective against 369 kinases with only ALK6 (41 nM) being inhibited) ALK1/2 inhibitor. Much higher kinome selectivity than the typically used ALK 1/2 inhibitor LDN-193189. MU1700 exhibits favorable pharmacokinetic and bioavailability profiles for in vivo use. It showed excellent CNS penetration with brain concentrations exceeding that in plasma.
- Shipping Conditions:
- Ambient