10-4692
PF-670462 dihydrochloride
Size
£168.00
- SKU:
- 10-4692
- Physical State:
- Solid
- Molecular Weight:
- 337.4
- Purity:
- >98%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 950912-80-8
- Immunogen:
- Kinase
- Extra Details:
- Potent inhibitor of casein kinase 1E Epsilon/D Delta (CK1E Epsilon, IC50 = 7.7 nM; CK1D Delta, IC50 = 14 nM).1 It is a circadian clock modifier that caused robust phase delays in rats1 and Cynomolgus monkeys2. PF-670462 caused nuclear retention of the clock protein PER resulting in period lengthening in a phase-specific manner that was dependent on CK1D Delta inhibition and not CK1E Epsilon.3 It improved cognitive performance and reduced amyloid load in various mouse models of Alzheimer's disease.4-6 PF-670462 slowed the progression of and increased survival of chronic lymphocytic leukemia in mice alone and in combination with Ibrutinib.7
- Shipping Conditions:
- Ambient