10-4691
JH-X-119-01
Size
£187.00
- SKU:
- 10-4691
- Additional Names:
- N-[4-[[3-(Prop-2-enoylamino)benzoyl]amino]phenyl]-6-(1H-pyrazol-5-yl)pyridine-2-carboxamide
- Physical State:
- Solid
- Molecular Weight:
- 452.47
- Purity:
- 98%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 2227368-54-7
- Immunogen:
- Kinase
- Extra Details:
- JH-X-119-01 is a highly selective (significantly inhibited only YSK4 and MEK3 in a panel of over 300 kinases) and potent (IC50 = 9 nM) covalent inhibitor of interleukin 1 receptor-associated kinase 1 (IRAK1). It displayed cytotoxic activity against several lymphoma cell lines and exhibited synergism with the BTK inhibitor Ibrutinib in the same systems. JH-X-119-01 protected mice from LPS-induced sepsis2 and ameliorated acute graft-versus-host disease in mice undergoing allogenic hematopoietic cell transplantation without effecting the anti-lymphoma effect3.
- Shipping Conditions:
- Ambient