10-4650
P505-15
Size
£173.00
- SKU:
- 10-4650
- Additional Names:
- BIIB-057|PRT062607
- Physical State:
- Solid
- Molecular Weight:
- 429.91
- Purity:
- >98%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 1370261-97-4
- Immunogen:
- Kinase
- Extra Details:
- P505-15 is a highly selective and potent (IC50 = 1-2 nM) inhibitor of spleen tyrosine kinase (Syk).1 It potently inhibited B cell antigen receptor-mediated B cell signaling/activation and basophil degranulation. It displayed anti-inflammatory activity in rodent models of rheumatoid arthritis. P505-15 displayed efficacy in vitro and in vivo in non-Hodgkin lymphoma and chronic lymphocytic leukemia models.2,3 It protected against toxin-induced hepatic fibrosis, associated hepatocellular injury, and hepatocarcinogenesis.4 P505-15 was also found to inhibit PINK1 (IC50 = 0.5-3 uM) in HeLa cells and dopaminergic neurons.5
- Shipping Conditions:
- Ambient