10-4642
Tegavivint
Size
£182.00
- SKU:
- 10-4642
- Additional Names:
- BC2059|Tegatrabetan
- Physical State:
- Solid
- Molecular Weight:
- 588.74
- Purity:
- 98%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 1227637-23-1
- Immunogen:
- Transcription factor
- Extra Details:
- Tegavivint is a potent inhibitor (IC50 = <10 nM) of the B Beta-catenin pathway.1 Active in vitro in multiple cancer cells with nanomolar potency. Tegavivint displayed efficacy in mouse models of acute myeloid leukemia2, multiple myeloma3, and mantle cell lymphoma4. It inhibits the B Beta-catenin pathway in a unique way by selectively binding to Transducin Beta-like related protein 1 (TBLR1) leading to displacement of B Beta-catenin from the TBL1/B Beta-catenin complex.5 This interaction does not effect Notch, Sonic Hedgehog, or Hippo signaling pathways. Tegavivint promotes a lipid-dependent nonapoptotic cell death that is dependent on the enzyme trans-2,3-enoyl-CoA reductase (TECR).6
- Shipping Conditions:
- Ambient