10-4633
Nitazoxanide
Size
£139.00
- SKU:
- 10-4633
- Physical State:
- Solid
- Molecular Weight:
- 307.28
- Purity:
- 99%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 55981-09-4
- Immunogen:
- Antibiotic
- Extra Details:
- Nitazoxanide is a clinically relevant antiparasitic agent.1It has since been repurposed as a broad-spectrum antiviral agent that is active against many RNA and DNA viruses including influenza, Hepatitis B and C, RSV, coronavirus, dengue and others.2 Its antiparasitic activity is believed to be due to inhibition of pyruvate:ferredoxin/flavodoxin oxidoreductases.3 Antiviral activity involves activation of protein kinase activated by double-stranded RNA (PKR) leading to phosphorylation of eukaryotic initiation factor 2 alpha (eIF2A Alpha).4 Nitazoxanide has also been found to inhibit Wnt signaling independent of adenomatous polyposis coli (APC) - it targets peptidyl arginine deiminase 2 (PAD2) resulting in increased citrullination of B Beta-catenin.5
- Shipping Conditions:
- Ambient