Clodronate 2Na

Size

£139.00

SKU:: 10-4631
Physical State:: Solid
Molecular Weight:: 360.92
Purity:: 98%
Storage Conditions:: -20[o]C
Supplier:: Focus Biomolecules
CAS Number:: 88416-50-6
Extra Details:: Clodronate is a first generation non-nitrogenous bisphosphonate drug for the prevention and treatment of osteoporosis and skeletal fractures/hypercalcemia in patients with cancer. It strongly binds to hydroxyapatite and directly reduces osteoclast activity.1 Clodronate is metabolized in vitro to a cytotoxic ATP analog (AppCCl2p) which inhibits ADP/ATP translocase in the mitochondrial inner membrane leading to osteoclast apoptosis.2