10-4629
Azoramide
Size
£149.00
- SKU:
- 10-4629
- Physical State:
- Solid
- Molecular Weight:
- 308.83
- Purity:
- 98%
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 932986-18-0
- Immunogen:
- ER/Golgi|UPR (Unfolded Protein Response)
- Extra Details:
- Azoramide is a modulator of the unfolded protein response (UPR).1 It improves endoplasmic reticulum (ER) protein folding and activates ER chaperone capacity to protect cells against ER stress. It displayed potent anti-diabetic activity in two mouse models by improving insulin sensitivity and pancreatic B Beta cell function. Azoramide increased SERCA expression leading to enhanced calcium retention in the ER indicating calcium homeostasis as a possible mechanism for its anti-diabetic acitivty.
- Shipping Conditions:
- Ambient