10-4624
TH1760
Size
£153.00
- SKU:
- 10-4624
- Physical State:
- Solid
- Molecular Weight:
- 426.45
- Purity:
- 98%
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 2567914-01-4
- Extra Details:
- Potent inhibitor (IC50 = 25 nM dGTP hydrolysis; 57 nM 6-thio-dGTP hydrolysis) of the NUDIX hydrolase NUDT15, an important enzyme involved in the hydrolysis thiopurine chemotherapeutics. It was selective against other human NUDIX proteins as well as a panel of 44 kinases and the Eurofins Cerep SafetyScreen44 panel. It was active in AML cell lines HL-60 and NB4 as well as HCT116 3-6 colorectal carcinoma cells and 697 B-ALL cells.
- Shipping Conditions:
- Ambient