10-4602
TH588
Size
£163.00
- SKU:
- 10-4602
- Physical State:
- Solid
- Molecular Weight:
- 331.63
- Purity:
- 98%
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 1609960-31-7
- Extra Details:
- TH588 is a first-in-class nudix hydrolase family inhibitor.1 MTH1/NUDT1 is a family member that "sanitizes" oxidized deoxynucleotide triphosphates (dNTP) preventing their incorporation into DNA and thus avoiding DNA damage and cell death. TH588 inhibits MTH1/NUDT1 (IC50 = 5 nM) leading to cell death in several cancer cell lines while not affecting normal cells. Active in vitro and in vivo. Recent evidence has raised doubts about the cancer-killing ability of MTH1 inhibition.2,3
- Shipping Conditions:
- Ambient