10-4578
Fumarate hydratase-IN-1
Size
£168.00
- SKU:
- 10-4578
- Physical State:
- Solid
- Molecular Weight:
- 446.55
- Purity:
- >98%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 1644060-37-6
- ABP:
- No Import Docs
- Extra Details:
- Fumarate hydratase-IN-1 is a pro-drug inhibitor of fumarate hydratase, an important enzyme in the tricarboxylic acid (TCA) cycle. This cell permeable compound is converted to the active carboxylic acid by intracellular esterases (Ki = 4.5 uM for free acid). The ethyl ester displayed cell-growth inhibitory activity against several cancer lines under nutrient (glucose) deprived conditions with an average IC50 = 2.2 uM.
- Shipping Conditions:
- Ambient