10-4572
L-Buthionine Sulfoximine
Size
£149.00
- SKU:
- 10-4572
- Physical State:
- Solid
- Molecular Weight:
- 222.31
- Purity:
- >98%
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 5072-26-4
- Immunogen:
- Glutathione
- Extra Details:
- Buthionine sulfoximine is an irreversible inhibitor of G Gamma-glutamylcysteine ligase (GCL). GCL is the first enzyme of the cellular glutathione biosynthetic pathway. Dysregulation of glutathione homeostasis is involved in many diseases including cancer, diabetes, neurodegenerative disorders and HIV/AIDS.1 Most disease states involve decreased glutathione synthesis, however, in cancer, it is increased supporting cellular proliferation and protecting cancer cells. Pharmacological inhibition of GCL has been examined as a potential cancer treatment.2-4
- Shipping Conditions:
- Ambient