NLG919

Size

£158.00

SKU:: 10-4564
Physical State:: Solid
Molecular Weight:: 282.39
Storage Conditions:: -20[o]C
Supplier:: Focus Biomolecules
CAS Number:: 1402836-58-1
Immunogen:: Tryptophan
Extra Details:: NLG919 (1402836-58-1) is a potent IDO-pathway inhibitor (Ki = 7nM; EC50 = 75nM).1 It synergizes with chemo-radiation therapy to promote T cell dependent complement deposition in a murine model of glioblastoma.2 In combination with paclitaxel in a mouse B16-F10 melanoma model, NLG919 increased the percentage of CD3+, CD8+, and CD4+ T cells and secretion of IFN-G Gamma and interleukin-2 while decreasing the percentage of CD4+CD25+ regulatory T cells.3