10-4556
CB-839
Size
£153.00
- SKU:
- 10-4556
- Additional Names:
- Telaglenastat
- Physical State:
- Solid
- Molecular Weight:
- 571.57
- Purity:
- >97%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 1439399-58-2
- Immunogen:
- Energy production|Glutaminase
- Extra Details:
- CB-839 is a potent (IC50 = 24 nM), selective and orally bioavailable inhibitor of glutaminase (KGA and GAC).1 CB-839 displayed an antiproliferative effect in the triple-negative breast cancer cell line, HCC-1806, but no activity in the estrogen receptor-positive cell line T47D. CB-839 was able to cause proliferation arrest and apoptosis in acute myeloid leukemia cells without causing cytotoxicity against normal human CD34(+) progenitors.2 Aspartate-glutamate carrier 1 (AGC1) inhibition can synergize with CB-839 to limit tumor growth.3
- Shipping Conditions:
- Ambient