10-4544
7-Cl-O-Nec1
Size
£158.00
- SKU:
- 10-4544
- Additional Names:
- Nec-1s|Necrostatin1-S
- Physical State:
- Solid
- Molecular Weight:
- 277.71
- Purity:
- 98%
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 852391-15-2
- Immunogen:
- Kinase
- Extra Details:
- Necrostatin-1 analogue with superior potency (IC50 = 206nM vs 494nM), selectivity and metabolic stability in blocking RIP1.1,2 7-Cl-O-Nec-1 shows no off-target inhibition of indolamine-2,3-deoxygenase (IDO) in contrast to Necrostatin-1 (Nec-1).3,4 7-Cl-O-Nec-1 showed higher activity in inhibiting necroptosis in Jurkat cells than Necrostatin-1 (EC50 = 210 nM vs. EC50 = 490 nM), no non-specific cytotoxicity at high concentrations (100 uM) and reasonable pharmacokinetic characteristics when used in mice.2 7-Cl-O-Nec-1 is recommended for cellular and in vivo use over Necrostatin-1.5
- Shipping Conditions:
- Ambient