10-4540
20(S)-Hydroxycholesterol
Size
£139.00
- SKU:
- 10-4540
- Physical State:
- Solid
- Molecular Weight:
- 402.66
- Purity:
- 98%
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 516-72-3
- Immunogen:
- GPCR
- Extra Details:
- 20-(S)-Hydroxycholesterol is an endogenous ligand for the LXR receptor.1 It has anti-adipogenic and pro-osteogenic effects in mesenchymal stem cells mediated via a non-LXR dependent pathway.2 The osteogenic effects of 20-(S)-hydroxycholesterol have been shown to be mediated by activation of hedgehog signaling and expression of genes associated with Notch signaling.3 Activation of Hedgehog is mediated via binding of 20(S)-hydroxycholesterol to Smoothened at a site distinct from the cyclopamine binding site.4,5
- Shipping Conditions:
- Ambient