10-4530
Tubastatin A HCl
Size
£153.00
- SKU:
- 10-4530
- Physical State:
- Solid
- Molecular Weight:
- 371.86
- Purity:
- 99%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 1310693-92-5
- Immunogen:
- Protein deacetylase
- Extra Details:
- Tubastatin A is a potent and highly selective inhibitor of HDAC6 (IC50 = 15 nM, >1000-fold selectivity against other HDAC isoforms, approx. 60-fold versus HDAC8).1 It displayed anti-inflammatory and anti-rheumatic effects in Freund's competitive adjuvant induced animal model of inflammation.2 Tubastatin A inhibited TNF-A Alpha (IC50 = 272 nM) and IL-6 (IC50 = 712 nM) in LPS stimulated human THP-1 macrophages.2 Tubastatin A has also been shown to have therapeutic potential for treatment of Alzheimers disease via altered amloid-B Beta load and reduced tau hyperphosphorylation.3,4,5
- Shipping Conditions:
- Ambient