HPI-1

Size

£173.00

SKU:: 10-4522
Physical State:: Solid
Molecular Weight:: 463.52 (anhydrous)
Purity:: >98%
Storage Conditions:: -20[o]C
Supplier:: Focus Biomolecules
CAS Number:: 599150-20-6
Extra Details:: HPI-1 is a Hedgehog pathway inhibitor acting downstream of Smo and independently of PKA, PI3K and MAPK. It can suppress Hh pathway activation induced by loss of Su(fu) or Gli overexpression. Inhibits both endogenous and exogenous Gli1/Gli2 activity. IC50's range from 0.2 to 6 uM for various cell-based assays.