10-4514
DAPT
Size
£153.00
- SKU:
- 10-4514
- Additional Names:
- LY-374973
- Physical State:
- Solid
- Molecular Weight:
- 432.46
- Purity:
- 98%
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 208255-80-5
- ABP:
- No Import Docs
- Immunogen:
- Protease
- Extra Details:
- Inhibitor of G Gamma-secretase (IC50 in human primary neurons = 115 nM for total AB Beta or 200 nM for AB Beta42 specifically)1. Oral administration of DAPT has been shown to reduce levels of AB Beta in brain extract, cerebrospinal fluid and plasma from mice and rats.2,3 DAPT blocks Notch signaling which promotes neuronal differentiation of precur-sor cells.4 Enhances iPS cells without oncogenes KLF4 and CMYC5. Cell permeable.
- Shipping Conditions:
- Ambient