10-4485
GS-441524
Size
£129.00
- SKU:
- 10-4485
- Physical State:
- Solid
- Molecular Weight:
- 291.27
- Purity:
- >98%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 1191237-69-0
- ABP:
- No Import Docs
- Immunogen:
- RNA
- Extra Details:
- Parent nucleoside and active metabolite of the SARS-CoV2 drug remdesivir. Displayed broad spectrum antiviral activity against HCV, YFV, DENV-2, influenza A, parainfluenza 3, and SARS-CoV.1 It has been suggested that GS-441524 is superior as an anti-SARS-CoV2 drug due to simplicity of preparation compared to remdesivir, lack of on-target liver toxicity, and the fact that remdesivir is prematurely hydrolyzed to GS-441524 in human serum.2 Additionally, the enzymes that hydrolyze remdesivir to active metabolite GS-441524 are hardly expressed in lungs.
- Shipping Conditions:
- Ambient