10-4474
Ganetespib
Size
£158.00
- SKU:
- 10-4474
- Additional Names:
- STA-9090
- Physical State:
- Solid
- Molecular Weight:
- 364.40
- Purity:
- 98%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 888216-25-9
- Immunogen:
- HSP (Heat shock protein)
- Extra Details:
- Ganetespib is an inhibitor of heat shock protein 90 (IC50 = 19 nM, canine C2 malignant mast cells; 4 nM, canine BR malignant mast cells) binding to the N-terminal ATP site.1 It displayed potent cytotoxicity against a panel of 57 transformed cell lines of both hematologic and solid tumors with IC50's between 14 and 280 nM.2 Ganetespib enhanced T-cell-mediated killing of human melanoma cells and potentiated responses to anti-CTLA4 and anti-PD1 therapy via upregulation of interferon response genes.3 In multiple clinical trials for various cancers.
- Shipping Conditions:
- Ambient