10-4473
Linrodostat
Size
£163.00
- SKU:
- 10-4473
- Additional Names:
- BMS-986205
- Physical State:
- Solid
- Molecular Weight:
- 410.92
- Purity:
- >98%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 1923833-60-6
- Immunogen:
- Tryptophan
- Extra Details:
- Linrodostat is an irreversible inhibitor (IC50 = 1.1 nM HEK293 cells; 1.7 nM HeLa cells) of indoleamine 2,3-dioxygenase 1 (IDO1), an enzyme that metabolizes tryptophan into immunosuppressive kynurenine.1,2,3 Acts synergistically with PD-1 inhibitors in various cancer models including bladder4, advanced solid tumors5, and hematologic5.
- Shipping Conditions:
- Ambient