10-4449
SBI-553
Size
£187.00
- SKU:
- 10-4449
- Physical State:
- Solid
- Molecular Weight:
- 450.56
- Purity:
- >98%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 1849603-72-0
- Immunogen:
- GPCR
- Extra Details:
- SBI-553 is a potent, brain penetrant, and orally bioavailable allosteric modulator of neurotensin receptor 1 (NTSR1; EC50 = 340 nM)).1 It acts as a B Beta-Arrestin-biased agonist and selectively antagonizes G protein signaling conferring profound B Beta-Arrestin bias towards the endogenous ligand.2,3 SBI-553 displayed efficacy in mouse models of psychostimulant abuse without the characteristic undesirable side effects of unbiased NTSR1 agonism. This functionally selective modulation of NTSR1 may be a new therapeutic approach to treating psychostimulant abuse and other chemical and behavioral addictions.
- Shipping Conditions:
- Ambient